Variables tecnológicas predictoras del estrés académico en estudiantes de Enfermería en tiempos de COVID-19 / Technological variables predictors of academic stress in nursing students in times of COVID-19 / Variáveis tecnológicas preditoras do estresse acadêmico em estudantes de Enfermagem em tempos de COVID-19

Objetivo: analizar cuáles son las variables tecnológicas, derivadas del uso de dispositivo electrónico, predicen el estrés académico, y sus dimensiones en estudiantes de enfermería. Método: estudio transversal de tipo analítico, realizado en 796 estudiantes de seis universidades de Perú. Se empleó la escala SISCO y para el análisis se estimaron cuatro modelos de regresión logística, con selección de variables por pasos. Resultados: entre los participantes, 87,6% presentaron un nivel alto de estrés académico; el tiempo de uso del dispositivo electrónico, el brillo de la pantalla, la edad y el sexo, estuvieron asociados con el estrés académico y sus tres dimensiones; la posición de uso del dispositivo electrónico estuvo asociada con la escala total y con las dimensiones estresores y reacciones. Finalmente, la distancia entre el rostro y el dispositivo electrónico estuvo asociada con la escala total y la dimensión reacciones. Conclusión: las variables tecnológicas y las características sociodemográficas predicen el estrés académico en estudiantes de enfermería. Se sugiere optimizar el tiempo de uso de las computadoras, regular el brillo de la pantalla, evitar sentarse en posiciones inadecuadas y vigilar la distancia, con la finalidad de reducir el estrés académico durante la enseñanza a distancia.

Objective: to analyze which technological variables, derived from the use of electronic devices, predict academic stress and its dimensions in Nursing students. Method: analytical cross-sectional study carried out with a total of 796 students from six universities in Peru. The SISCO scale was used and four logistic regression models were estimated for the analysis, with selection of variables in stages. Results: among the participants, 87.6% had a high level of academic stress; time using the electronic device, screen brightness, age and sex were associated with academic stress and its three dimensions; the position of using the electronic device was associated with the total scale and the stressors and reactions dimensions. Finally, the distance between the face and the electronic device was associated with the total scale and size of reactions. Conclusion: technological variables and sociodemographic characteristics predict academic stress in nursing students. It is suggested to optimize the time of use of computers, regulate the brightness of the screen, avoid sitting in inappropriate positions and pay attention to the distance, in order to reduce academic stress during distance learning.

Objetivo: analisar quais variáveis tecnológicas, derivadas do uso de dispositivos eletrônicos, predizem o estresse acadêmico e suas dimensões em estudantes de enfermagem. Método: estudo transversal do tipo analítico, realizado em 796 estudantes de seis universidades do Peru. Foi utilizada a escala SISCO e foram estimados quatro modelos de regressão logística para a análise, com seleção das variáveis por etapas. Resultados: entre os participantes, 87,6% apresentaram alto nível de estresse acadêmico; o tempo de uso do aparelho eletrônico, o brilho da tela, a idade e o sexo foram associados ao estresse acadêmico e suas três dimensões; a posição de uso do aparelho eletrônico foi associada à escala total e às dimensões estressores e reações. Por fim, a distância entre o rosto e o dispositivo eletrônico foi associada à escala total e à dimensão das reações. Conclusão: variáveis tecnológicas e características sociodemográficas predizem estresse acadêmico em estudantes de Enfermagem. Sugere-se otimizar o tempo de uso dos computadores, regular o brilho da tela, evitar sentar-se em posições inadequadas e atentar-se à distância da tela, a fim de diminuir o estresse acadêmico durante o ensino a distância.

Perceptions, maltreatment and religion as predictors of the psycho-emotional impact on nurses during the COVID-19 pandemic.

OBJECTIVES: to analyze the relationship between perceptions, abuse and religion with the psycho-emotional impact on nurses during the COVID-19 pandemic. METHODS: descriptive-analytical cross-sectional study. It took place between 2020 and 2021 and a total of 319 clinical nurses in Peru were interviewed using the DASS-21. Associations were assessed using Spearman's Rho and multiple regression. RESULTS: 18.5% had some degree of stress; 50.2%, anxiety and 29.1%, depression. Experience of abuse, self-perception of mental health and religion were predictors of stress, anxiety and depression. The length of work experience predicts stress and anxiety. In addition, self-perception of information and gender were predictors of depression. CONCLUSIONS: peruvian nurses have high levels of stress, anxiety and depression, and this psycho-emotional impact was associated with perceptions, experiences of abuse and religion.

Desarrollo y validación de una escala de percepción de riesgo de COVID-19 en Perú / Development and validation of a COVID-19 risk perception scale in Peru

RESUMEN Objetivos. Desarrollar y validar una escala de percepción de riesgo ante la COVID-19 (PR-COVID-19-PE) en población peruana. Materiales y métodos. Estudio transversal psicométrico, realizado en el 2022. En la fase 1 se diseñó la escala inicial mediante revisión teórica, grupos focales, panel de expertos y revisión documental de escalas. En la fase 2 se determinó la escala mediante juicio de expertos y una prueba piloto. En la fase 3 se hizo una encuesta virtual en 678 pobladores peruanos adultos. Se efectuó un análisis factorial confirmatorio. Para determinar la validez de criterio se realizó un análisis correlacional (r de Pearson) con una escala válida de percepción de riesgo y la escala de miedo a la COVID-19. Resultados. La PR-COVID-19-PE está compuesta por dos dimensiones (cognitivo y emocional), presentó buen ajuste en la validez de constructo (x2/gl=2,34, Comparative Fit Index = 0,96, Tucker-Lewis Index = 0,96, Root Mean Square Error of Approximation = 0,05 y Standarized Root Mean-Square = 0,07) y óptima consistencia interna (ώ=0,88). Asimismo, reportó correlación con otra escala de percepción de riesgo ante la COVID-19 (r=0,70, p<0,001) y miedo a la COVID-19 (r = 0,41, p < 0,001). Además, presenta invarianza métrica y escalar tanto por sexo como por nivel educativo. Conclusiones. La escala PR-COVID-19-PE presentó adecuada confiabilidad y validez de contenido, constructo y criterio. Constituye un instrumento para medir la percepción de riesgo ante la COVID-19 en poblaciones similares. Sin embargo, se requiere estudios adicionales en diferentes grupos poblacionales.

ABSTRACT Objectives. To develop and validate a risk perception scale for COVID-19 (PR-COVID-19-PE) in the Peruvian population. Materials and methods. Psychometric cross-sectional study conducted in 2022. In phase 1, in order to design the scale, we carried out a theoretical review and a documentary review of scales, we also used focus groups as well as an expert panel. Phase 2 included expert judgment and a pilot test. A virtual survey was conducted among 678 Peruvian adults during phase 3. A confirmatory factor analysis was carried out as well. We used a correlational analysis (Pearson's r) with a valid risk perception scale and the COVID-19 fear scale to determine criterion validity. Results. The PR-COVID-19-PE has two dimensions (cognitive and emotional) and showed good fit during construct validity (x2/gl=2.34, Comparative Fit Index=0.96, Tucker-Lewis Index=0.96, Root Mean Square Error of Approximation= 0.05 and Standardized Root Mean-Square=0.07) and optimal internal consistency (ώ=0.88). Likewise, the PR-COVID-19-PE showed correlation with another COVID-19 risk perception scale (r=0.70, p< 0.001) and a fear of COVID-19 scale (r=0.41, p<0.001). In addition, it presents metric and scalar invariance by both sex and educational level. Conclusions. The PR-COVID-19-PE scale showed adequate reliability and content, construct and criterion validity. It is an instrument that can measure COVID-19 risk perception in similar populations. However, further studies are required for different populations.

Effectiveness of the self-regulation educational program in increasing knowledge about COVID-19 in Peruvian soldiers.

OBJECTIVE: To determine the effectiveness of the educational program based on self-regulation of learning in the level of knowledge about COVID-19 in the soldiers. METHODS: Pre-experimental study with a pre-test and post-test design with a single group, carried out in 2020. 179 soldiers from Puno, Peru participated. Two expository-participatory sessions and a demonstrative workshop were developed. A valid (Aiken's V = 0.69) and reliable (McDonald's Omega = 0.81) questionnaire was used. The Friedman's test was used to compare the results pre and post-test. RESULTS: The level of knowledge about COVID-19 and in two of its dimensions changed from poor (pre-test) to regular (post-test). However, in the preventive measures dimension, it changed from poor (pre-test) to excellent (post-test). CONCLUSION: The proposed educational intervention was effective in increasing knowledge about COVID-19 in the soldiers, mainly in terms of preventive measures.

Technological variables predictors of academic stress in nursing students in times of COVID-19. / Variables tecnológicas predictoras del estrés académico en estudiantes de Enfermería en tiempos de COVID-19.

OBJECTIVE: to analyze which technological variables, derived from the use of electronic devices, predict academic stress and its dimensions in Nursing students. METHOD: analytical cross-sectional study carried out with a total of 796 students from six universities in Peru. The SISCO scale was used and four logistic regression models were estimated for the analysis, with selection of variables in stages. RESULTS: among the participants, 87.6% had a high level of academic stress; time using the electronic device, screen brightness, age and sex were associated with academic stress and its three dimensions; the position of using the electronic device was associated with the total scale and the stressors and reactions dimensions. Finally, the distance between the face and the electronic device was associated with the total scale and size of reactions. CONCLUSION: technological variables and sociodemographic characteristics predict academic stress in nursing students. It is suggested to optimize the time of use of computers, regulate the brightness of the screen, avoid sitting in inappropriate positions and pay attention to the distance, in order to reduce academic stress during distance learning.

analizar cuáles son las variables tecnológicas, derivadas del uso de dispositivo electrónico, predicen el estrés académico, y sus dimensiones en estudiantes de enfermería. estudio transversal de tipo analítico, realizado en 796 estudiantes de seis universidades de Perú. Se empleó la escala SISCO y para el análisis se estimaron cuatro modelos de regresión logística, con selección de variables por pasos. entre los participantes, 87,6% presentaron un nivel alto de estrés académico; el tiempo de uso del dispositivo electrónico, el brillo de la pantalla, la edad y el sexo, estuvieron asociados con el estrés académico y sus tres dimensiones; la posición de uso del dispositivo electrónico estuvo asociada con la escala total y con las dimensiones estresores y reacciones. Finalmente, la distancia entre el rostro y el dispositivo electrónico estuvo asociada con la escala total y la dimensión reacciones. las variables tecnológicas y las características sociodemográficas predicen el estrés académico en estudiantes de enfermería. Se sugiere optimizar el tiempo de uso de las computadoras, regular el brillo de la pantalla, evitar sentarse en posiciones inadecuadas y vigilar la distancia, con la finalidad de reducir el estrés académico durante la enseñanza a distancia.

(1) Los estudiantes de enfermería presentan un nivel alto de estrés académico. (2) El tiempo de uso de la computadora es un predictor del estrés académico. (3) El brillo de la pantalla de la computadora es un predictor del estrés académico. (4) Tener entre 30 a 39 años y ser hombre es un factor protector del estrés académico. (5) Estudio realizado en seis universidades peruanas.

analisar quais variáveis tecnológicas, derivadas do uso de dispositivos eletrônicos, predizem o estresse acadêmico e suas dimensões em estudantes de enfermagem. estudo transversal do tipo analítico, realizado em 796 estudantes de seis universidades do Peru. Foi utilizada a escala SISCO e foram estimados quatro modelos de regressão logística para a análise, com seleção das variáveis por etapas. entre os participantes, 87,6% apresentaram alto nível de estresse acadêmico; o tempo de uso do aparelho eletrônico, o brilho da tela, a idade e o sexo foram associados ao estresse acadêmico e suas três dimensões; a posição de uso do aparelho eletrônico foi associada à escala total e às dimensões estressores e reações. Por fim, a distância entre o rosto e o dispositivo eletrônico foi associada à escala total e à dimensão das reações. variáveis tecnológicas e características sociodemográficas predizem estresse acadêmico em estudantes de Enfermagem. Sugere-se otimizar o tempo de uso dos computadores, regular o brilho da tela, evitar sentar-se em posições inadequadas e atentar-se à distância da tela, a fim de diminuir o estresse acadêmico durante o ensino a distância.

Association between the Nursing Practice Environment and Safety Perception with Patient Safety Culture during COVID-19.

AIMS: In this study, we aimed to identify the relationship between nursing practice environments (NPEs) and safety perceptions with patient safety culture (PSC) during COVID-19. DESIGN: We conducted a quantitative, non-experimental, correlational, and cross-sectional study. We interviewed 211 nurses from Peru using two scales: PES-NWI and HSOPSC. We used the Shapiro-Wilk test and Spearman's coefficient and estimated two regression models. RESULTS: NPE was reported as favorable by 45.5% of the participants, and PSC was reported as neutral by 61.1%. Safety perception, the workplace, and NPE predict PSC. All NPE factors were correlated with PSC. However, safety perception, support of nurses subscale, the nurse manager's ability, and leadership were predictors of PSC. CONCLUSION: To promote a safe work culture, health institutions should foster leadership that prioritizes safety, strengthens managers' abilities, encourages interprofessional collaboration, and considers nurses' feedback for constant improvement.

Digital Eye Strain among Peruvian Nursing Students: Prevalence and Associated Factors.

There has been a high prevalence of digital eye strain (DES) among students who have received distance-learning lessons due to COVID-19. However, in low- and middle-income countries, there are few studies that have analyzed its associated factors. This study aimed to determine the prevalence of DES and its associated factors among nursing students during COVID-19 distance learning. This was a cross-sectional analytical study conducted between May and June 2021 in six Peruvian universities. The sample comprised 796 nursing students. DES was measured using the Computer Vision Syndrome Questionnaire (CVS-Q). A bivariate logistic regression analysis was performed. DES was found in 87.6% of nursing students. Sitting upright (OR, 0.47; 95% IC, 0.30-0.74), using electronic devices for more than four hours a day (OR, 1.73; 95% IC, 1.02-2.86), not following the 20-20-20 rule (OR, 2.60; 95% IC, 1.25-5.20), having the screen brightness very high (OR, 3.36; 95% IC, 1.23-11.8), and not wearing glasses (OR, 0.59; 95% IC, 0.37-0.93) are factors associated with DES. The prevalence of DES among nursing students is high. Improving the ergonomics of study environments, reducing the time of exposure to electronic devices, adjusting the screen brightness, and taking eye-care measures are key to controlling computer vision syndrome in virtual learning.

Effectiveness of the self-regulation educational program in increasing knowledge about COVID-19 in Peruvian soldiers / Efetividade do Programa Educacional de Autorregulação no Aumento do Conhecimento da COVID-19 em Militares Peruanos / Efectividad del Programa educativo de autorregulación en incrementar conocimientos sobre COVID-19 en militares peruanos

ABSTRACT Objective: To determine the effectiveness of the educational program based on self-regulation of learning in the level of knowledge about COVID-19 in the soldiers. Methods: Pre-experimental study with a pre-test and post-test design with a single group, carried out in 2020. 179 soldiers from Puno, Peru participated. Two expository-participatory sessions and a demonstrative workshop were developed. A valid (Aiken's V = 0.69) and reliable (McDonald's Omega = 0.81) questionnaire was used. The Friedman's test was used to compare the results pre and post-test. Results: The level of knowledge about COVID-19 and in two of its dimensions changed from poor (pre-test) to regular (post-test). However, in the preventive measures dimension, it changed from poor (pre-test) to excellent (post-test). Conclusion: The proposed educational intervention was effective in increasing knowledge about COVID-19 in the soldiers, mainly in terms of preventive measures.

RESUMO Objetivo: determinar a efetividade do programa educacional baseado na autorregulação da aprendizagem a respeito do nível de conhecimento da COVID-19 em militares. Métodos: estudo pré-experimental de desenho pré-teste e pós-teste com um grupo só, realizado em 2020. Participaram 179 militares de Puno, Peru. Duas sessões expositivo-participativas e uma oficina demonstrativa foram desenvolvidas. Foi utilizado um questionário válido (V de Aiken = 0,69) e fiável (Ômega de McDonald = 0,81). O teste de Friedman foi empregado para comparar os resultados em pré e pós-teste. Resultados: o nível de conhecimento sobre a COVID-19 em duas das dimensões mudou de deficiente (pré-teste) para regular (pós-teste). Contudo, na dimensão de medidas preventivas, passou de deficiente (pré-teste) para excelente (pós-teste). Conclusão: a intervenção educacional proposta foi eficaz no aumento do conhecimento da COVID-19 entre os militares, principalmente em termos de medidas preventivas.

RESUMEN Objetivo: Determinar la efectividad del Programa educativo basado en autorregulación del aprendizaje en el nivel de conocimiento sobre COVID-19 en militares. Métodos: Estudio preexperimental de diseño pretest y postest con un solo grupo, realizado en 2020. Participaron 179 militares de Puno, Perú. Se desarrollaron dos sesiones expositivo-participativas y un taller demostrativo. Se empleó un cuestionario válido (V de Aiken = 0,69) y confiable (Omega de McDonald = 0,81). Se utilizó el test de Friedman para comparar los resultados en pre y postest. Resultados: El nivel de conocimientos sobre COVID-19 y en dos de sus dimensiones cambió de deficiente (pretest) a regular (postest). Sin embargo, en la dimensión medidas preventivas, cambió de deficiente (pretest) a excelente (postest). Conclusión: La intervención educativa propuesta fue efectiva al incrementar los conocimientos sobre COVID-19 en militares, principalmente en cuanto a medidas preventivas.

Development and validation of a COVID-19 risk perception scale in Peru. / Desarrollo y validación de una escala de percepción de riesgo de COVID-19 en Perú.

OBJECTIVES.: Motivation for the study. Risk perception of COVID-19 is a construct that varies according to the characteristics of the population in each geographic area; however, there is no validated scale to measure this construct in the Peruvian population. Main findings. A COVID-19 risk perception scale composed of two dimensions (cognitive and emotional) was designed and validated using qualitative and quantitative techniques. Implications. Having a valid and reliable instrument will help identify the variation of risk perception of COVID-19 according to contextual and psychological factors in the Peruvian population. . To develop and validate a risk perception scale for COVID-19 (PR-COVID-19-PE) in the Peruvian population. MATERIALS AND METHODS.: Psychometric cross-sectional study conducted in 2022. In phase 1, in order to design the scale, we carried out a theoretical review and a documentary review of scales, we also used focus groups as well as an expert panel. Phase 2 included expert judgment and a pilot test. A virtual survey was conducted among 678 Peruvian adults during phase 3. A confirmatory factor analysis was carried out as well. We used a correlational analysis (Pearson's r) with a valid risk perception scale and the COVID-19 fear scale to determine criterion validity. RESULTS.: The PR-COVID-19-PE has two dimensions (cognitive and emotional) and showed good fit during construct validity (x2/gl=2.34, Comparative Fit Index=0.96, Tucker-Lewis Index=0.96, Root Mean Square Error of Approximation= 0.05 and Standardized Root Mean-Square=0.07) and optimal internal consistency (ώ=0.88). Likewise, the PR-COVID-19-PE showed correlation with another COVID-19 risk perception scale (r=0.70, p< 0.001) and a fear of COVID-19 scale (r=0.41, p<0.001). In addition, it presents metric and scalar invariance by both sex and educational level. CONCLUSIONS.: The PR-COVID-19-PE scale showed adequate reliability and content, construct and criterion validity. It is an instrument that can measure COVID-19 risk perception in similar populations. However, further studies are required for different populations.

OBJETIVOS.: Desarrollar y validar una escala de percepción de riesgo ante la COVID-19 (PR-COVID-19-PE) en población peruana. MATERIALES Y MÉTODOS.: Estudio transversal psicométrico, realizado en el 2022. En la fase 1 se diseñó la escala inicial mediante revisión teórica, grupos focales, panel de expertos y revisión documental de escalas. En la fase 2 se determinó la escala mediante juicio de expertos y una prueba piloto. En la fase 3 se hizo una encuesta virtual en 678 pobladores peruanos adultos. Se efectuó un análisis factorial confirmatorio. Para determinar la validez de criterio se realizó un análisis correlacional (r de Pearson) con una escala válida de percepción de riesgo y la escala de miedo a la COVID-19. RESULTADOS.: La PR-COVID-19-PE está compuesta por dos dimensiones (cognitivo y emocional), presentó buen ajuste en la validez de constructo (x2/gl=2,34, Comparative Fit Index = 0,96, Tucker-Lewis Index = 0,96, Root Mean Square Error of Approximation = 0,05 y Standarized Root Mean-Square = 0,07) y óptima consistencia interna (ώ=0,88). Asimismo, reportó correlación con otra escala de percepción de riesgo ante la COVID-19 (r=0,70, p<0,001) y miedo a la COVID-19 (r = 0,41, p < 0,001). Además, presenta invarianza métrica y escalar tanto por sexo como por nivel educativo. CONCLUSIONES.: La escala PR-COVID-19-PE presentó adecuada confiabilidad y validez de contenido, constructo y criterio. Constituye un instrumento para medir la percepción de riesgo ante la COVID-19 en poblaciones similares. Sin embargo, se requiere estudios adicionales en diferentes grupos poblacionales.

Perceptions, maltreatment and religion as predictors of the psycho-emotional impact on nurses during the COVID-19 pandemic / Percepções, maltrato e religião como preditores do impacto psicoemocional em enfermeiros durante a pandemia de COVID-19 / Percepciones, maltrato y religión como predictores del impacto psicoemocional en enfermeros durante la pandemia COVID-19

ABSTRACT Objectives: to analyze the relationship between perceptions, abuse and religion with the psycho-emotional impact on nurses during the COVID-19 pandemic. Methods: descriptive-analytical cross-sectional study. It took place between 2020 and 2021 and a total of 319 clinical nurses in Peru were interviewed using the DASS-21. Associations were assessed using Spearman's Rho and multiple regression. Results: 18.5% had some degree of stress; 50.2%, anxiety and 29.1%, depression. Experience of abuse, self-perception of mental health and religion were predictors of stress, anxiety and depression. The length of work experience predicts stress and anxiety. In addition, self-perception of information and gender were predictors of depression. Conclusions: peruvian nurses have high levels of stress, anxiety and depression, and this psycho-emotional impact was associated with perceptions, experiences of abuse and religion.

RESUMO Objetivos: analisar a relação entre percepções, abuso e religião com o impacto psicoemocional nos enfermeiros durante a pandemia de COVID-19. Métodos: estudo transversal descritivo-analítico. Realizado entre 2020 e 2021; foram entrevistados 319 enfermeiros assistenciais no Peru por meio do DASS-21; as associações foram avaliadas usando Rho de Spearman e regressão múltipla. Resultados: 18,5% apresentaram algum grau de estresse; 50,2%, ansiedade e 29,1%, depressão. Experiência de abuso, autopercepção de saúde mental e religião foram preditores de estresse, ansiedade e depressão. O tempo de experiência de trabalho prediz estresse e ansiedade. Além disso, a autopercepção das informações e o gênero foram preditores de depressão. Conclusões: os enfermeiros peruanos apresentam altos níveis de estresse, ansiedade e depressão; e esse impacto psicoemocional foi associado a percepções, experiências de abuso e religião.

RESUMEN Objetivos: analizar la relación entre percepciones, maltrato y religión con el impacto psicoemocional en enfermeros durante la pandemia por covid-19. Métodos: estudio transversal descriptivo-analítico. Fue realizado entre los años 2020 y 2021; se encuestó a 319 enfermeros asistenciales de Perú mediante DASS-21; se evaluaron asociaciones mediante Rho de Spearman y regresión múltiple. Resultados: el 18,5 % presentó algún grado de estrés; el 50,2 %, ansiedad y el 29,1 %, depresión. La experiencia de maltrato, la autopercepción de la salud mental y la religión fueron predictores de estrés, ansiedad y depresión. El tiempo de experiencia laboral predice el estrés y ansiedad. Además, la autopercepción de la información y el género fueron predictores de la depresión. Conclusiones: los enfermeros peruanos presentaron altos niveles de estrés, ansiedad y depresión; y este impacto psicoemocional estuvo asociado a las percepciones, experiencias de maltrato y la religión.

Asociación entre la salud mental positiva y habilidades sociales en estudiantes de enfermería / Associação entre saúde mental positiva e habilidades sociais em estudantes de enfermagem / Association between positive mental health and social skills in nursing students

Resumen Contexto: Los estudiantes de Enfermería (EE) tienen un alto nivel de salud mental positiva (SMP), aspecto que desde un enfoque positivo fue asociado con las habilidades blandas la autocompasión, resiliencia, empatía y autoeficacia; sin embargo, pocos estudios analizaron la relación entre la SMP y las habilidades sociales (HS) como conducta socialmente habilidosa para comportarse de manera asertiva. Objetivo: Determinar la asociación entre la SMP y las HS en EE de tres universidades del Perú. Metodología: Estudio transversal, descriptivo y correlacional, realizado en el año 2020 mediante un formulario Google Forms. Se empleó la escala de SMP (Lluch Canut, 2000) y la escala de HS (Gismero, 2010). La muestra estuvo conformada por 392 EE seleccionados por muestreo no probabilístico por conveniencia. Para determinar la asociación se aplicaron dos modelos de regresión lineal múltiple, con un nivel de significancia de 0,01. Resultados: Se encontró que los EE tenían un nivel alto de SMP (73,5%), nivel medio de HS (57,9%). Las variables que se relacionan con la SMP de manera positiva fueron: la ocupación (B=0,11, p<0,05), autoexpresión en situaciones sociales (B=0,52, p<0,001), habilidad de hacer peticiones (B=0.18, p<0.001) y las HS (B=0.55, p<0.001); y de manera negativa, la expresión de enfado o disconformidad (B= -0,11, p=0,04) Conclusiones: Existe asociación entre la SMP y las HS; por lo tanto, para mantener el nivel alto de SMP que tienen los EE se sugiere implementar intervenciones multidisciplinarias dirigidas al fortalecimiento de las HS, particularmente en quienes solo se dedican a estudiar.

Resumo Contexto: Os estudantes de Enfermagem (EE) têm um alto nível de saúde mental positiva (SMP), um aspecto que, de um enfoque positivo, foi associado com as habilidades interpessoais de autocompaixão, resiliência, empatia e autoeficácia; contudo, poucos estudos analisaram a relação entre a SMP e as habilidades sociais (HS) como conduta socialmente hábil para comportar-se de forma assertiva. Objetivo: Determinar a associação entre a SMP e as HS nos EE em três universidades no Peru. Metodologia: Estudo transversal, descritivo e correlacional, realizado no ano de 2020 mediante um formulário do Google Forms. Utilizou-se a escala de SMP (Lluch, 2000) e a escala de HS (Gismero, 2010). A amostra consistiu em 392 EE seleccionados por amostragem não probabilística por conveniencia. Para determinar a associação, foram aplicados dois modelos de regressão linear múltipla, com nível de significância de 0,01. Resultados: Foi encontrado que os EE têm um alto nível de SMP (73,5%) e um médio nível de HS (57,9%). As variáveis que estão relacionadas à SMP de modo positivo foram: ocupação (B = 0,11, p < 0,05), autoexpressão em situações sociais (B = 0,55, p < 0,001); e negativamente, a expressão de raiva ou desacordo (B = -0,11, p = 0,04). Conclusões: Há uma associação entre SMP e HS; portanto, para manter o alto nível de SMP que os EE possuem, sugere-se a implementação de intervenções multidisciplinares voltadas ao fortalecimento de HS, principalmente naqueles que se dedicam apenas aos estudos.

Abstract Context: Nursing students (NS) have a high level of positive mental health (PMH), an aspect that since a positive approach was associated with the soft skills of self-compassion, resilience, empathy and self-efficacy; however, few studies have analyzed the relationship between PMH and social skills (SS) as a socially capable behavior to behave in an assertive manner. Objective: To determine the association between the PMH and the SS in NS of three universities in Peru. Methodology: Cross-sectional, descriptive and correlational study, carried out in 2020 using a Google Forms form. The PMH scale (Lluch Canut, 2000) and the SS scale (Gismero, 2010) were used. The sample consisted of 392 NS selected by non-probabilistic convenience sampling. To determine the association, two multiple linear regression models were applied, with a significance level of 0.01. Results: NS were found to have a high level of PMH (73,5%), a medium level of SS (57.9%). The variables that are related to the PMH in a positive way were: occupation (B=0,11, p<0,05), self-expression in social situations (B=0,52, p<0,001), ability to make requests (B=0.18, p<0.001) and SS (B=0.55, p<0.001); and negatively, the expression of anger or disagreement (B= -0,11, p=0,04) Conclusions: There is an association between PMH and SS; therefore, to maintain the high level of PMH that NS have, it is suggested to implement multidisciplinary interventions aimed at strengthening the SS, particularly in those who only dedicate themselves to study.

Asociación entre los estilos de crianza y el rol de los adolescentes peruanos en el acoso escolar, 2019 / Association between parenting styles and the role of Peruvian adolescents in bullying, 2019 / Associação entre estilos parentais e o papel de adolescentes peruanos no bullying, 2019

Introducción. Los estilos de crianza determinan la conducta infantil; sin embargo, existe escasa información sobre su repercusión en el acoso escolar. Objetivo: Determinar la fuerza de asociación entre las diferentes tipologías de los estilos de crianza y el rol asumido en el acoso escolar, así como identificar perfiles de los adolescentes según su involucramiento en el acoso escolar. Materiales y métodos. Estudio transversal tipo analítico, realizado en Lima-Perú, en el año 2019. Se aplicó la escala de estilos de crianza de Steinberg y la escala EBIP-Q a 563 escolares de escuelas públicas. Los puntajes fueron obtenidos mediante un análisis factorial confirmatorio. Se empleó el coeficiente de correlación de Spearman, Chi Cuadrado de Pearson y análisis de regresión logística multinomial. Resultados. Existe asociación entre los estilos de crianza y el rol del adolescente en el acoso escolar. El análisis multivariado reportó que ser hombres se asocia con el rol de agresor (OR = 2,73); mientras que acceder a una red social (OR = 2,23), ser hombre (OR = 1,75), los estilos de crianza (negligente [OR = 2,72] y mixto [OR = 0,38] en comparación con autoritario) fueron predictores de asumir el rol de agresor victimizado en el acoso escolar. Discusión. La asociación encontrada en el estudio confirma hallazgos previos; sin embargo, se abre debate sobre la influencia del estilo de crianza negligente en la dinámica del acoso escolar. Conclusión. Tanto el estilo de crianza negligente y autoritario (menor proporción) tienen un efecto positivo y significativo en el rol de agresor victimizado.

Introduction: Parenting styles determine child behavior; however, there is little information on their impact on bullying. Objective: To determine the association between different parenting styles and the role assumed in bullying, as well as to identify adolescents' profiles according to their involvement in bullying. Materials and Methods: A cross-sectional analytical study was conducted in Lima, Peru, in 2019. The Steinberg's Parenting Styles Scale and the European Bullying Intervention Project Questionnaire (EBIP-Q) were administered to 563 students from public schools. Scores were obtained by confirmatory factor analysis. Spearman's correlation coefficient, Pearson's Chi-square test, and multinomial logistic regression analysis were used. Results: There is an association between parenting styles and adolescents' role in bullying. The multivariate analysis reported that being male was associated with the role of the bully (OR: 2.73; 95% CI 1.59­4.68), while access to social media (OR: 2.23; CI 95% 1.11­4.49), being male (OR: 1.75; CI=1.06­2.88), and parenting styles (neglectful [OR: 2.72; 95% CI 1.32­5.59] and mixed [OR: 0.38; 95% CI 0.16­0.91] compared to authoritarian parenting style) were predictors of the role of the victimized bully. Discussion: The association found in the study confirms previous findings; however, it opens the debate on the influence of neglectful parenting style on bullying dynamics. Conclusions: Both neglectful and authoritarian parenting styles (lower proportion) have a positive and significant effect on the role of victimized bully.

Introdução: Os estilos parentais determinam o comportamento das crianças; no entanto, há pouca informação sobre o seu impacto no bullying. Objetivo: Determinar a força da associação entre os diferentes estilos parentais e o papel assumido no bullying; bem como identificar perfis de adolescentes de acordo com seu envolvimento no bullying. Materiais e métodos: Estudo analítico transversal realizado em Lima-Peru em 2019. A escala de estilos parentais de Steinberg e a escala EBIP-Q foram aplicadas a 563 alunos de escolas públicas. Os escores foram obtidos por meio de uma análise fatorial confirmatória. Foram utilizados o coeficiente de correlação de Spearman, o Qui-Quadrado de Pearson e a análise de regressão logística multinomial. Resultados: Existe associação entre os estilos parentais e o papel do adolescente no bullying. A análise multivariada relatou que ser do sexo masculino está associado ao papel de agressor (OR: 2,73; IC 95% 1,59-4,68); ao acessar uma rede social (OR: 2,23; IC 95% 1,11-4,49), ser do sexo masculino (OR: 1,75; IC=1,06-2,88), estilos parentais (negligente [OR: 2,72; IC 95% 1,32-5,59] e misto [OR: 0,38; IC 95% 0,16-0,91] comparado ao autoritário) foram preditores de assumir o papel de agressor vitimizado no bullying. Discussão: A associação encontrada no estudo confirma achados anteriores; no entanto, abre-se um debate sobre a influência do estilo parental negligente na dinâmica do bullying. Conclusão: Tanto o estilo parental negligente quanto o autoritário (menor proporção) têm efeito positivo e significativo no papel do agressor vitimizado.

Resignificación de la vida por parte de jóvenes sobrevivientes al cáncer hematológico / Resignification of Life by Young People Survivors of Hematologic Cancer

Introducción: Los jóvenes con enfermedades oncológicas enfrentan dificultades durante los períodos de diagnóstico, tratamiento y recuperación. Estos procesos complejos cargados de experiencias vitales inusitadas producen la transformación de su conciencia y los lleva a construir nuevos significados en la manera de comprender, relacionarse y actuar en el mundo que los rodea. Objetivo: Comprender el (re)significado de la vida a partir de la experiencia de los jóvenes que sobrevivieron al cáncer hematológico. Métodos: Estudio cualitativo, que utilizó la Teoría Fundamentada en Datos como metodología y el referencial de la Teoría de la Complejidad de Morin. Se realizaron entrevistas en profundidad a 12 adolescentes sobrevivientes de cáncer hematológico. El tamaño de muestra fue determinado al alcanzar nivel de saturación. El análisis fue simultáneo durante la recolección de los datos, mediante codificación abierta, axial y selectiva según lo señalan Strauss y Corbin. Resultados: Emergieron dos categorías: Reorganizando su vida por medio de cambios y aprendizajes para vencer al cáncer y, Asumiendo una mejor comprensión y compromiso con los demás y consigo mismo. Conclusiones: Las experiencias vividas por jóvenes sobrevivientes que padecen de cáncer modifican su forma de vivir y se tornan más comprensivos con el sufrimiento que ocasiona la enfermedad. Esta situación los hace más solidarios y comprometidos con su contexto social sobre todo con su familia y con pacientes oncológicos(AU)

Introduction: Young people with oncological diseases face difficulties during the periods of diagnosis, treatment and recovery. These complex processes loaded with unusual life experiences produce the transformation of their consciousness and lead them to construct new meanings in the way that they understand, relate and act in the world around them. Objective: To understand the (re)signification of life from the experience of young survivors of hematological cancer. Methods: A qualitative study was carried out, using the data driven theory as the methodology and Morin's complexity theory as the referent. In-depth interviews were conducted with twelve adolescent hematologic cancer survivors. The sample size was determined by reaching the saturation level. The analysis was simultaneous during data collection, using open, axial and selective coding according to Strauss and Corbin. Results: Two categories emerged: 1. reorganizing their life through changes and learning to overcome cancer and 2. assuming a better understanding and commitment to others and to themselves. Conclusions: The experiences lived by young cancer survivors modify their way of living as they become more understanding of the suffering caused by the disease. This situation makes them more supportive and committed to their social context, especially with their family and with cancer patients(AU)

Worry and fear as predictors of fatalism by COVID-19 in the daily work of nurses. / Preocupação e medo como preditores de fatalismo por COVID-19 no cotidiano de trabalho dos enfermeiros.

OBJECTIVE: to analyze the relationship between the concern and fear of COVID-19 with fatalism in the daily work of nurses. METHOD: analytical cross-sectional study carried out with a total of 449 nurses. Data collection was performed using instruments validated in Peru. In the analysis, the Shapiro-Wilk test and the Spearman correlation coefficient were used, and two multiple regression models were estimated, with variable selection in stages. RESULTS: nurses had a moderate level of fatalism and a low level of fear and concern about COVID-19. The first statistical model, which included sociodemographic variables, explains only 3% of the fatalism variance. However, a second model that includes fear and perception explains 33% of it. CONCLUSION: Worry, fear and having been diagnosed with COVID-19 were predictors of fatalism. It is suggested the implementation of psycho-emotional interventions in daily work - aimed at Nursing professionals who present high levels of fear or concern - to reduce fatalism and prevent fatal consequences of the pandemic and promote health.

NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruvian patients.

BACKGROUND: In Peru, 32,970 people were diagnosed with tuberculosis (TB) in 2019. Although TB treatment is effective, 3.4%-13% is associated with significant adverse drug reactions (ADR), considering drug-induced liver injury (DILI) as the most prevalent. Among the first-line anti-TB drugs, isoniazid (INH) is primarily responsible for the occurrence of DILI. INH is metabolized in the liver by the enzymes N-acetyltransferase-2 (NAT2) and Cytochrome P450 2E1 (CYP2E1). Based on the previous studies, we hypothesized that the interactions between slow CYP2E1 genotype and NAT2 slow acetylators will induce DILI in TB patients. METHODS: In this cross-sectional study, all 377 participants completed their anti-TB treatment, and we genotyped SNPs: rs1041983, rs1801280, rs1799929, rs1799930, rs1208, and rs1799931 for NAT2 and rs3813867 and rs2031920 for CYP2E1. RESULTS: We found that rapid, intermediate, and slow NAT2 acetylator were 15%, 38%, and 47%, respectively, in the general population. Intermediate NAT2 acetylator is the least prevalent among patients with adverse reactions (p = 0.024). We did not confirm our hypothesis, however, we found that the combination of intermediate NAT2 acetylators and CYP2E1 c1/c1 genotype significantly protected (OR = 0.16; p = 0.049) against the development of DILI in our population. CONCLUSION: We propose that the presence of NAT2 intermediate and CYP2E1 c1/c1 genotype could help in therapeutic drug monitoring, and optimize its therapeutic benefits while minimizing its risk for side effects or toxicity.

Conocimiento sobre sistemas de denuncia del acoso escolar y tipo de intervención del adolescente espectador / Knowledge about School Bullying Reporting Systems and the Type of Intervention of the Adolescent Witness

Introducción: El acoso escolar constituye un problema de salud pública por su repercusión en el presente y futuro de los escolares, donde el rol de espectador cobra cada día mayor relevancia. Objetivo: Describir los conocimientos sobre los sistemas de denuncia del acoso escolar y tipo de intervención del adolescente espectador en escuelas públicas de Lima. Métodos: Estudio descriptivo transversal realizado en 668 estudiantes de escuelas públicas ubicadas en Lima, Perú, entre agosto y diciembre del 2019. Muestreo no probabilístico por conveniencia. Mediante la encuesta y empleo de un cuestionario se evaluó el tipo de intervención ante el acoso escolar y el conocimiento sobre sistemas de denuncia del acoso escolar. Para el análisis de los datos se empleó la prueba estadística de Chi Cuadrado de Pearson con un nivel de significancia p < 0,05. Resultados: Presenció una situación de violencia escolar entre pares el 59,82 por ciento, de ellos 63,34 por ciento intervino ante esa situación. Hubo diferencias estadísticamente significativas en el porcentaje de escolares que intervinieron según sexo y año de estudios. El 51,39 por ciento defendió a la víctima o conversó con el agresor. En cuanto al conocimiento de sistemas de reporte de violencia escolar, 24,21 por ciento conocía SiSeve y 64,73 por ciento conocía la DEMUNA. Conclusiones: El principal tipo de intervención de los estudiantes que fueron espectadores ante una situación de acoso escolar fue defender a la víctima o conversar con el agresor. Por otra parte, existe escaso conocimiento de la existencia de SiseVe entre los escolares, aunque la mayoría conocía la DEMUNA(AU)

Introduction: School bullying is a public health concern due to its impact on the present and future of schoolchildren, where the role of bystander becomes more relevant every day. Objective: To describe the knowledge about the systems for reporting bullying and the type of intervention of adolescent bystanders in public schools in Lima. Methods: Cross-sectional and descriptive study carried out with 668 students chosen from public schools in Lima, Peru, by nonprobabilistic convenience sampling between August and December 2019. A survey and a questionnaire permitted to assess the type of intervention in the face of bullying and knowledge about systems for reporting bullying. Pearson's chi-square test was used for data analysis with a significance level of P<0.05. Results: A situation of school violence among peers was witnessed by 59.82 percent of the respondents, 63.34 percent of which intervened in this situation. Based on sex and year of study, there were statistically significant differences in the percentage of schoolchildren who intervened. 51.39 percent defended the victim or talked with the aggressor. Regarding knowledge about school violence reporting systems, 24.21 percent know about the existence of SiSeve, while 64.73 percent knew DEMUNA. Conclusions: The main type of intervention of students who witnessed a bullying situation was to defend the victim or talk with the aggressor. On the other hand, there is little knowledge about the existence of SiseVe among the students, although most of them knew about DEMUNA(AU)

Validation of a Bullying Scale in Peruvian Adolescents and Gender-Specific Differences.

The objective of the study was to evaluate the psychometric properties of the European Bullying Intervention Project Questionnaire (EBIPQ) inPeruvian adolescents and to determine gender-specific differences. The sample comprised 532 students in sixth grade of elementary school to third grade of high school. To validate the instrument, we requested an expert judgement and conducted a pilot test. Subsequently, we performed the exploratory factorial analysis, which showed that all the questions were correctly loaded in both components, an aspect that explained the 48.6%variance. We determined the reliability by means of the internal-consistency method using the Cronbach's alfa (αtotal= .856;αvictimization= .807;αaggression= .828). We found gender-specific differences in bullying roles(p<.001). In conclusion, the factorial structure of the EBIPQ in Peruvian adolescents is similar to the original questionnaire and presents high reliability and construct validity.

El estudio tuvo como objetivo evaluar las propiedades psicométricas del European Bullying Intervention Project Questionnaire (EBIPQ) en adolescentes peruanos y determinar sus diferencias según el género. La muestra estuvo conformada por 532 escolares de sexto grado de Primaria a tercer grado de Secundaria. Para la validez del contenido, se realizó el juicio de expertos y una prueba piloto. Posteriormente, se realizó el análisis factorial exploratorio, el cual mostró que todas las preguntas fueron cargadas en forma correcta en los dos componentes, lo que explica el 48.6% de varianza. La confiabilidad se estableció mediante el método de consistencia interna, a través del Alfa de Cronbach (αtotal=.856;αvictimización= .807;αagresión= .828). Se encontraron diferenciasen el rol de acoso escolar según el género (p<.001).En conclusión, la estructura factorial del EBIPQ en adolescentes peruanos es similar al cuestionario original y presenta elevada confiabilidad y validez de constructo.

Validation of the Steinberg Parenting Styles Scale in Peruvian adolescents.

Introduction: There are numerous scales of parenting styles adapted for Peruvian adolescents. In addition, some report a structural model that does not match the model of the original version. Objective: Evaluate the psychometric properties of the Steinberg's Parenting Styles Scale in Peruvian adolescents. Method: The sample included 563 students. A model of relationships in three dimensions is confirmed: involvement, psychological autonomy, and parental supervision. Results: The analysis suggested the elimination of five items. The resulting scale shows a good fit: χ 2 = 469.051, df = 184, χ 2 /df = 2.54, CFI = .95, TLI = .94, RMSEA = .053, SRMR = .063. Likewise, it shows an optimal internal consistency determined by the McDonald's omega index. Conclusion: The internal structure of the questionnaire was similar to the original questionnaire and presented adequate reliability and construct validity. however, additional studies with larger age range samples and different Peruvian subcultures are required to achieve its generalization.

Introducción: Existen numerosas escalas de estilos de crianza adaptadas para adolescentes peruanos. Además, algunos reportan un modelo estructural que no coincide con el modelo de la versión original. Objetivo: Evaluar las propiedades psicométricas de la escala de estilos de crianza de Steinberg en adolescentes peruanos. Método: La muestra integró 563 estudiantes. Se confirma un modelo de relaciones en tres dimensiones: compromiso, autonomía psicológica y control parental. Resultados: El análisis sugirió la eliminación de cinco ítems. La escala resultante muestra un buen ajuste: χ 2 = 469.051, df = 184, χ 2 /df = 2.54, CFI=.95, TLI=.94, RMSEA=.053, SRMR=.063. Así mismo, da cuenta de una óptima consistencia interna determinada por el índice Omega McDonald. Conclusión: La estructura interna del cuestionario fue similar al cuestionario original y presentó adecuada confiabilidad y validez de constructo. Sin embargo, se requieren estudios adicionales con muestras de mayor rango de edad y diferentes subculturas peruanas para lograr su generalización.

Preocupação e medo como preditores de fatalismo por COVID-19 no cotidiano de trabalho dos enfermeiros / Worry and fear as predictors of fatalism by COVID-19 in the daily work of nurses / Preocupación y miedo como predictores de fatalismo por COVID-19 en lo cotidiano laboral de enfermeros

Resumo Objetivo: analisar a relação entre a preocupação e o medo da COVID-19 com o fatalismo no cotidiano de trabalho dos enfermeiros. Método: estudo transversal analítico, realizado com 449 enfermeiros. A coleta de dados foi realizada por meio de instrumentos validados no Peru. Na análise, foram utilizados o teste de Shapiro-Wilk e o coeficiente de correlação de Spearman, sendo estimados dois modelos de regressão múltipla, com seleção de variáveis por etapas. Resultados: os enfermeiros apresentaram nível moderado de fatalismo e baixo nível de medo e preocupação com a COVID-19. O primeiro modelo estatístico, que incluiu variáveis sociodemográficas, explica apenas 3% da variância de fatalismo. No entanto, um segundo modelo que inclui medo e percepção explica 33%. Conclusão: a preocupação, o medo e ter sido diagnosticado com COVID-19 foram fatores preditores de fatalismo. Sugere-se a implementação de intervenções psicoemocionais no cotidiano de trabalho, voltadas para profissionais de Enfermagem que apresentem altos níveis de medo ou preocupação, para reduzir o fatalismo e, assim, prevenir consequências fatais da pandemia e promover a saúde.

Abstract Objective: to analyze the relationship between the concern and fear of COVID-19 with fatalism in the daily work of nurses. Method: analytical cross-sectional study carried out with a total of 449 nurses. Data collection was performed using instruments validated in Peru. In the analysis, the Shapiro-Wilk test and the Spearman correlation coefficient were used, and two multiple regression models were estimated, with variable selection in stages. Results: nurses had a moderate level of fatalism and a low level of fear and concern about COVID-19. The first statistical model, which included sociodemographic variables, explains only 3% of the fatalism variance. However, a second model that includes fear and perception explains 33% of it. Conclusion: Worry, fear and having been diagnosed with COVID-19 were predictors of fatalism. It is suggested the implementation of psycho-emotional interventions in daily work - aimed at Nursing professionals who present high levels of fear or concern - to reduce fatalism and prevent fatal consequences of the pandemic and promote health.

Resumen Objetivo: analizar la relación entre la preocupación y el miedo al COVID-19 con el fatalismo, en lo cotidiano laboral de los enfermeros. Método: estudio transversal tipo analítico, realizado en 449 enfermeros. La recolección de datos se realizó mediante instrumentos validados en Perú. En el análisis se utilizó la prueba de Shapiro-Wilk, el coeficiente de correlación de Spearman y se estimaron dos modelos de regresión múltiple, con selección de variables por pasos. Resultados: los enfermeros presentaron un nivel moderado de fatalismo y un nivel bajo de miedo y preocupación por la COVID-19. El primer modelo estadístico que incluyó las variables sociodemográficas apenas explica un 3% de la varianza de fatalismo; sin embargo, un segundo modelo que incluye el miedo y la percepción explica el 33%. Conclusión: la preocupación, el miedo y el haber sido diagnosticado con COVID-19 fueron factores predictores de fatalismo. Se sugiere implementar intervenciones psicoemocionales en el cotidiano laboral - focalizadas en profesionales de Enfermería que presenten altos niveles de miedo o preocupación - para reducir el fatalismo y de esta manera prevenir consecuencias fatales de la pandemia y promover la salud.

Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients.

BACKGROUND: We determined the frequency of genetic polymorphisms in three anti-TB drug metabolic proteins previously reported: N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1), and arylacetamide deacetylase (AADAC) within a Peruvian population in a cohort of TB patients. METHODS: We genotyped SNPs rs1041983, rs1801280, rs1799929, rs1799930, rs1208, and rs1799931 for NAT2; rs3813867 and rs2031920 for CYP2E1; and rs1803155 for AADAC in 395 participants completed their antituberculosis treatment. RESULTS: Seventy-four percent of the participants are carriers of slow metabolizer genotypes: NAT2*5, NAT2*6, and NAT2*7, which increase the sensitivity of INH at low doses and increase the risk of drug-induced liver injuries. Sixty-four percent are homozygous for the wild-type CYP2E1*1A allele, which could increase the risk of hepatotoxicity. However, 16% had a NAT2 fast metabolizer phenotype which could increase the risk of acquiring resistance to INH, thereby increasing the risk of multidrug-resistant (MDR) or treatment failure. The frequency of rs1803155 (AADAC*2 allele) was higher (99.9%) in Peruvians than in European American, African American, Japanese, and Korean populations. CONCLUSIONS: This high prevalence of slow metabolizers for isoniazid in the Peruvian population should be further studied and considered to help individualize drug regimens, especially in countries with a great genetic diversity like Peru. These data will help the Peruvian National Tuberculosis Control Program develop new strategies for therapies.